John Tower

John Tower Link to laboratory: http://dornsife.usc.edu/cf/bisc/faculty_display.cfm?Person_ID=1003772

How will your research contribute to extending healthy human life?

We are using the laboratory fruit fly Drosophila to identify genes and pathways that affect aging and that are conserved in humans.  These studies have identified promising genetic and chemical interventions to pursue in future human studies.

What were the major breakthroughs made by your laboratory or companies?

Our research suggests that aging results in part from sex-specific trade-offs between reproduction and mitochondrial maintenance, including costly sex-specific metabolic regulation and compromised immune function.  The data indicate that the conserved p53 and Foxo genes are regulators of sex-specific trade-offs, and are therefore promising targets for sex-specific interventions in human aging.  Moreover, our studies implicate the Xist gene as one master regulator of these trade-offs in humans, and suggest that Xist and its downstream genes are promising targets for future human aging interventions. Finally, we have found that the drug mifepristone/RU486 can increase the life span of mated female Drosophila by over +70%, suggesting that further studies of mifepristone and related drugs in aging are warranted.

Can your research be commercialized in the future and is there any way to invest in this research today?

Yes there are many ways this research can be commercialized.  Our technologies, including Xist-based RNA therapeutics, can be licensed for commercial development by outside companies through the University of Southern California (USC). Several mechanisms are also available for commercial investment in the aging research ongoing in the Tower lab.  These opportunities include partnerships with USC and the Tower lab in the development and testing of aging interventions appropriate for commercial development. We encourage inquires from interested potential research partners; please contact John Tower via email for further information on these opportunities.

Do you think there will be significant breakthroughs in longevity research in the next decade?

Yes.  I think that sex-specific interventions in metabolism, dosage compensation, stem cell function, mitochondrial maintenance and immune function show promise for human longevity interventions in the near future.

Do you think it is a good time for iVAO to get into longevity business and invest in biotechnology in general?

Yes, as this is an area that is likely to expand in the near future.

Can you say a few words about the upcoming conference in St. Petersburg? What are your expectations?

I look forward to hearing about the latest advances in aging research from the leaders in the field.

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