Preliminary Program

25 April 2016, Monday

09.00-10.00

Opening of a conference

Andrey Fomenko, Alexey Moskalev, Vladimir Skulachev, Igor Tihonovich, Sergey Inge-Vechtomov, Vladimir Anisimov, Andrei Lisitsa

10.00-10.40

Brian Kennedy

Gender-specific effects of the mTOR pathway on metabolism and aging

10.40-11.10

Claudio Franceschi

Decelerated aging in semi-supercentenarians and their offspring according to the epigenetic clock

11.10-11.30

Andrei Gudkov

Origin, biological significance and pharmacological targeting of senescent cells in vivo

11.30-12.00

Coffee break

12.00-12.30

Dixit Vishwa

Inflammasome and age-related inflammation

12.30-12.50

Igor Kovalchuk

Epigenetics of aging – from mechanisms to preventative strategies

12.50-13.20

Wolfgang Wagner

Simple Epigenetic Biomarkers for Biological Age

13.20-13.40

Jan Vijg

Genome instability: A conserved mechanism of Aging?

13.40-14.00

Yousin Suh

Functional genomics approach to develop targets for slowing aging in humans

14.00-14.30

Guang-Hui Liu

Using stem cell and gene editing techniques to study and treat aging-associated disorders

14.30-15.30

Lunch

15.30-15.50

Vadim Gladyshev

Lifespan control across species and model systems

15.50-16.10

Andrey Seluanov

Longevity mechanisms in the the naked mole rat and other long-lived mammals

16.10-16.30

John Tower

Sex-specific regulation of life span in Drosophila

16.30-16.50

Vadim Fraifeld

Mitochondria: a bottleneck of aging and longevity?

17.30-18.00

Vera Gorbunova

The mechanisms of more efficient DNA repair in long-lived mammals: the role of SIRT6

18.00-18.20

Blanka Rogina

Indy reduction maintains fly health and homeostasis

18.20-18.35

Elena Pasyukova

Neuronal transcriptional regulators of lifespan in Drosophila melanogaster

18.35-18.50

Irina Irincheeva

Why don't we all lose weight equally on Caloric Restriction? Proteomics explanation to weight loss variability on a low calorie diet in overweight and obese subjects

18.50-19.05

Alexander Kulminski

Uncoupling associations of risk alleles with endophenotypes and phenotypes: Insights from the Apolipoprotein B locus, lipids, myocardial infarction, and survival

26 April 2016, Tuesday

09.00-09.30

Claudio Franceschi

Why centenarians are centenarians

09.30-10.10

Vladimir Skulachev

Naked Mole Rats and Humans: Highly Social Creatures Prolonging Youth by Delay of Ontogenesis (Neoteny)

10.10-10.30

David Gems

The origins of senescent pathology in C. elegans

10.30-10.50

Vadim Gladyshev

The rising deleteriome

10.50-11.10

Arnold Mitnitski

A dynamical network model for age-related accumulation of health deficits and mortality

11.10-11.30

Michal Jazwinski

Metabolic and Genetic Markers of Biological Age

11.30-12.00

Coffee break

12.00-12.20

Daniel Belsky

Quantification of biological aging in young adults

12.40-13.10

Andreas Simm

Biomarkers of Ageing: the what-where from-when questions

13.10-13.40

Tamas Fülöp

Are there any reliable biomarkers for immunosenescence?

13.40-14.00

Joao Pedro de Magalhaes

Gene expression profiling for the discovery of biomarkers of ageing

14.00-14.30

Arnold Mitnitski

Indices of biological aging as indicators of heterogeneity of people’s health

14.30-15.30

Lunch

15.30-15.55

Alexander Kulminski

Can age-specific genetic effects be relevant to biological age?

15.55-16.05

Natalia Marmiy

8-Oxo-2'-deoxyguanosine - a biomarker of aging and/or a possible tool for biomedical prevention/treatment of age-related diseases?

16.05-16.25

Alex Zhavoronkov

Gamification of data collection for deep learning and biomarker development

16.25-16.45

Alexander Fedintsev

Markers of cardiovascular health for human chronological and biological age estimation

16.45-17.00

Velegzhaninov Ilya

Evaluation of different types of DNA damage and CpG methylation levels in the peripheral blood leukocytes of mice as potential aging biomarkers

17.00-17.20

Vyacheslav Krut’ko

Bioage assessment and mortality trends

17.20-17.40

Peter Fedichev

Target and biomarker identification platform to design new drugs against aging and age-related diseases

17.40-18.10

Anatoliy Yashin

Lack of Replication in GWAS of Complex Traits: Insights for Efficient Analyses of Human Aging and Longevity

18.10-18.30

Alexander Maslov

Quantitative assessment of genome integrity by high-throughput sequencing: application for aging research

18.30-19.00

Philipp Khaitovich

27 April, Wednesday

09.00-09.30

Matt Kaeberlein

Effects of transient mid-life rapamycin treatment on lifespan and healthspan

09.30-10.00

Stephen Spindler

Flies, mice and humans, and the search for longevity therapeutics

10.00-10.30

James Mitchell

Increased endogenous hydrogen sulfide as a conserved mechanism of longevity extension

10.30-10.50

Mikhail Blagosklonny

Dual mTOR inhibitors decelerate and even reverse geroconversion

10.50-11.10

Maxim Skulachev

Development of mitochondrially-targeted geroprotectors: from the molecular design to clinical trials and marketing strategy

11.10-11.30

Sibylle Jager

Longevity compounds for skin anti-aging: promising strategy or false hope

11.30-12.00

Coffee break

12.00-12.15

Andrey Voronkov

Polypharmacological geroprotectors for healthy longevity

12.15-12.30

Alexey Moskalev

Geroprotectors study on Drosophila model

12.30-12.55

Vladimir Anisimov

Light desynchronosis, cancer and aging

12.55-13.10

Mikhail Shaposhnikov

Effect of Sun/klaroid gene deletion on lifespan, stress resistance, locomotor activity and fertility in Drosophila melanogaster

13.10-13.25

Ekaterina Proshkina

The influence of Gclc overexpression on the lifespan and circadian rhythms of Drosophila melanogaster

13.25-13.50

Evgeny Rogaev

Aging, Genomics, Alzheimer' Disease

13.50-14.05

Sergey Kozin

Aged isoform of β-amyloid as biomarker and drug target of Alzheimer’s disease

14.05-14.30

Anatoliy Yashin

Genetics of Alzheimer’s Disease: Insights for Studying Connection among Health, Aging, and Longevity

14.30-15.30

Lunch

15.30-15.45

Rosie Freer

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease

15.45-16.00

Natalia Stefanova

Prefrontal cortex transcriptomic indices of sporadic Alzheimer's disease in human and in a rat model

16.00-16.20

Olga Kovalchuk

Chemo brain and aging – is there a link?

16.20-16.40

Yuri Orlov

Bioinformatic analysis of the transcriptome of the brain of laboratory animals for studies of aggressive behavior

16.40-17.00

Vasily Popov

Methylene blue rejuvenates behavior and induces brain mitochondria biogenesis in aging mice

17.10-17.50

Khusru Asadullah

Trends in translation medicine: the value of external innovation

17.50-18.00

Closing of a conference

28 April, Thursday, bookshop "Bukvoed", address: Vladimirsky, 23

Presentation of the books "The potential geroprotectors" and "Biomarkers of of aging", the author - Alexey Moskalev

13.00-13.45

Ekaterina Proshkina

The genetics of aging and longevity

14.00-14.45

Alexey Moskalev

Genes, Diet, Longevity